European journal of clinical investigation
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Eur. J. Clin. Invest. · Apr 2023
Cancer Patients with Venous Thromboembolism: Diagnostic and Prognostic Value of Elevated D-dimers.
D-dimer testing is known to have a high sensitivity at simultaneously low specificity, resulting in nonspecific elevations in a variety of conditions. ⋯ Although D-dimer testing in cancer patients is discouraged by current guidelines, very high concentrations above the 10-fold upper reference limit contain diagnostic and prognostic information and might be helpful in risk assessment, while low concentrations remain useful for ruling out VTE.
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Eur. J. Clin. Invest. · Apr 2023
Statin Use is Associated with Better Post-Operative Prognosis Among Patients with Hepatitis B Virus-Related Hepatocellular Carcinoma.
The high postoperative recurrence rate of hepatocellular carcinoma (HCC) is a significant challenge. Patient metabolic factors are potential disease modifiers and should be examined as risk factors for postoperative prognosis. Here, we assessed the association between long-term statin use and HCC recurrence after surgical resection of hepatitis B virus (HBV)-related HCC. ⋯ Long-term statin use was significantly associated with reduced risk of HCC recurrence and liver-related mortality after curative resection of HBV-related HCC.
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Eur. J. Clin. Invest. · Apr 2023
LncRNA BBOX1-AS1 targets miR-361-3p/COL1A1 axis to drive the progression of esophageal carcinoma.
Oesophageal carcinoma (EC) is one of the types of prevalent malignant cancer in the globe. Many researchers reported the vital role played by long-coding RNAs in EC. In the current research, we investigated the mechanisms of the action of lncRNA BBOX1-AS1 in EC progression. ⋯ BBOX1-AS1 facilitated the EC development and malignancy via miR-361-3p/COL1A1 axis, indicating BBOX1-AS1 could be a novel therapy target for the diagnostic of EC.
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Eur. J. Clin. Invest. · Apr 2023
The gut microbiome dysbiosis is recovered by restoring a normal diet in hypercholesterolemic pigs.
Gut microbiota is thought to modulate cardiovascular risk. However, the effect of cardiovascular primary prevention strategies on gut microbiota remains largely unknown. This study investigates the impact of diet and rosuvastatin interventions on gut microbiota composition in hypercholesterolemic pigs and associated potential changes in host metabolic pathways. ⋯ In hypercholesterolemic animals, the ingestion of a low-fat diet for 30 days modifies gut microbiota composition in favour of alpha-diversity and towards a healthy metabolic profile, whereas rosuvastatin treatment for this period exerts no effects.