European journal of clinical investigation
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Eur. J. Clin. Invest. · Mar 2023
Effects of pharmacological inhibition of hyaluronic acid synthesis on experimental endometriosis.
Dysregulated hyaluronic acid (HA) metabolism has been shown to be implicated in several pathologies including endometriosis. 4-Methylumbelliferone (4MU) is an HA synthesis inhibitor with proven antitumour activity. In this study, we aim to evaluate the effect of 4MU on endometriosis development both in vivo and in vitro. ⋯ The inhibition of HA synthesis could be a beneficial and alternative option to treat endometriosis at the early stage of the disease. Further research is necessary to elucidate 4MU's mechanism of action and better strategies for delivering this promising drug.
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Eur. J. Clin. Invest. · Mar 2023
Retraction Of Publication Retracted PublicationCirc_0008078 inhibits EC cell tumor properties by miR-191-5p-dependent regulation of ELOVL4.
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Eur. J. Clin. Invest. · Feb 2023
Randomized Controlled Trial Multicenter StudyEarly administration of tofacitinib in COVID-19 pneumonitis: An open randomised controlled trial.
Controversies on sub-populations most sensitive to therapy and the best timing of starting the treatment still surround the use of immunomodulatory drugs in COVID-19. ⋯ High-dose tofacitinib therapy in patients with COVID pneumonitis is safe and may prevent deterioration to respiratory failure.