European journal of clinical investigation
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Eur. J. Clin. Invest. · Mar 2005
Multicenter StudyEradication of Helicobacter pylori increases platelet count in patients with idiopathic thrombocytopenic purpura in Japan.
The effect of Helicobacter pylori eradication on the platelet count in patients with thrombocytopenic purpura is controversial. In this multicentre study, we prospectively assessed the effect of H. pylori eradication therapy in idiopathic thrombocytopenic purpura patients. ⋯ Helicobacter pylori infection played a role in the pathogenesis of idiopathic thrombocytopenic purpura in approximately 30% of all patients assessed and 45% of the patients with H. pylori infection. Eradication of H. pylori in idiopathic thrombocytopenic purpura patients led to improved disease activity.
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Eur. J. Clin. Invest. · Mar 2003
Randomized Controlled Trial Multicenter Study Clinical TrialTopical butyrate improves efficacy of 5-ASA in refractory distal ulcerative colitis: results of a multicentre trial.
The treatment of distal ulcerative colitis, refractory to conventional 5-ASA/steroid treatment, is still a matter of debate. The present study aimed at confirming, with adequate statistical power, previous data indicating the usefulness of topical butyrate and 5-ASA in the treatment of this condition. ⋯ The combined treatment with topical butyrate and 5-ASA is significantly more effective than 5-ASA alone in the management of refractory distal colitis. Further improvements in the treatment of refractory distal ulcerative colitis may be feasible based on the identification of patient subgroups and the association of two or more active drugs. Butyrate may well be one of them.