Lancet
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Adults who had been drinking alcohol were admitted to hospital with severe lacticacidosis and died within two days. Empirical treatment with thiamine proved to be a cure for the disorder, for it was acute pernicious or fulminating beriberi. Thiamine deficiency is neglected as a cause of lacticacidosis.
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Randomized Controlled Trial Clinical Trial
Controlled trial of adjuvant chemotherapy with cyclophosphamide, methotrexate, and fluorouracil for breast cancer.
327 patients with cancer of the breast and involvement of axillary lymph nodes were randomised, after total mastectomy and axillary clearance, to receive either no additional treatment or oral cyclophosphamide 80 mg/m2 on days 1-14, intravenous methotrexate 32 mg/m2 on days 1 and 8, and intravenous fluorouracil 480 mg/m2 on days 1 and 8 (CMF), which was repeated every 28 days for twelve cycles. There was a significantly longer relapse-free survival (RFS) in patients treated with CMF. ⋯ Dose of chemotherapy did not have a significant effect on RFS. Survival was not influenced by treatment.