Lancet
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The calculation of the anion gap is widely used in the diagnosis of metabolic acidosis. It is often taught that the increment in the anion gap will exactly match the fall in serum bicarbonate during a simple metabolic acidosis of the high anion gap type; if the changes in the anion gap and bicarbonate level are not equivalent, a second acid-base disorder should be suspected. ⋯ This review critically examines these assumptions and their clinical implications. Discrepancies between the increment in the anion gap and the reduction in serum bicarbonate must be interpreted cautiously.
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Letter Comparative Study
Urokinase versus tissue plasminogen activator in pulmonary embolism.
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Randomized Controlled Trial Comparative Study Clinical Trial
Trial of high-dose Edmonston-Zagreb measles vaccine in Guinea-Bissau: protective efficacy.
In a randomised study of 558 children in an urban African community, the protective effect of the Edmonston-Zagreb (EZ) measles vaccine given in a dose of 40,000 plaque forming units from the age of 4 months was compared with the effects of a standard dose (6000 tissue culture infectious units) of Schwarz measles vaccine given from the age of 9 months. During two years of follow-up, all 14 clinical cases of measles occurred in the Schwarz group; 10 of the children contracted measles before vaccination and 4 after measles vaccination. Thus the EZ vaccine provided significant protection against measles both before and after the usual age of vaccination. Among the children who were exposed to measles at home, those given EZ vaccine were better protected than either unvaccinated children or those given the Schwarz vaccine.