Lancet
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Randomized Controlled Trial Comparative Study Clinical Trial
Randomised trial of oral morphine for painful episodes of sickle-cell disease in children.
Oral controlled-release morphine can provide effective analgesia through a non-invasive route and may facilitate outpatient management of severe episodes of sickle-cell pain. We compared the clinical efficacy and safety of oral morphine with continuous intravenous morphine in children with severe episodes of sickle-cell pain, by a double-blind, randomised, parallel-group design. ⋯ Oral, controlled-release morphine is a reliable, non-invasive alternative to continuous intravenous morphine for the management of painful episodes of sickle-cell disease in children.
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Comment Letter Historical Article
Molecular evidence for tuberculosis in an ancient Egyptian mummy.