The Medical clinics of North America
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Med. Clin. North Am. · May 1992
ReviewMicrocytic anemia. Differential diagnosis and management of iron deficiency anemia.
Microcytic anemia is defined as the presence of small, often hypochromic, red blood cells in a peripheral blood smear and is usually characterized by a low MCV (less than 83 micron 3). Iron deficiency is the most common cause of microcytic anemia. The absence of iron stores in the bone marrow remains the most definitive test for differentiating iron deficiency from the other microcytic states, ie, anemia of chronic disease, thalassemia, and sideroblastic anemia. ⋯ The vast majority of patients respond effectively to inexpensive and usually well-tolerated oral iron preparations. In the rare circumstances of malabsorption, losses exceeding maximal oral replacement, or true intolerance, parenteral iron dextran is effective. In either form of treatment, it is necessary to replete iron stores in addition to correcting the anemia.
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Transfusion of red blood cells is useful in restoring oxygen-carrying capacity in patients with symptomatic anemia. In general, physicians should avoid transfusing blood based on hemoglobin concentration alone. Instead, they should focus on the impact of anemia on the patient's symptoms and level of activity. ⋯ These concerns should be carefully considered, along with possible alternatives, before a decision is made to transfuse. It is important to define the cause of anemia and to institute appropriate corrective therapy. The availability of recombinant human erythropoietin offers an option in selected patients to reduce or eliminate the need for red blood cell transfusion.
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Med. Clin. North Am. · May 1992
ReviewHypoplastic/aplastic anemia. Role of bone marrow transplantation.
For young patients with SAA, allogeneic bone marrow transplantation is the best curative approach. Major obstacles to the success of allogeneic bone marrow transplantation include GVHD, infections, and graft rejection. ⋯ Immunosuppressive therapy should be utilized in older patients with SAA. Underlying clonal disorders, eg, acute leukemia and recurrent aplasia, are late complications.