Medicine
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Randomized Controlled Trial Multicenter Study
Different dosages of mifepristone versus enantone to treat uterine fibroids: A multicenter randomized controlled trial.
To evaluate the efficacy and safety of 10 mg and 25 mg mifepristone per day compared with 3.75 mg enantone in treating uterine fibroids. ⋯ 10mg is as effective as 25mg mifepristone and 3.75 mg enantone with minimal drug-related side effects, and may provide an alternative for clinical application, especially for patient who are in perimenopause with uterine fibroids.
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This study aimed to evaluate the associations of serum ferritin with insulin resistance indices, body fat mass/percentage, and all the components of metabolic syndrome (MetS), as well as the risk for MetS according to serum ferritin levels in Korean adolescents and adults. A total of 15,963 Korean males and females aged 16 to 80 years were analyzed using data from the Korean National Health and Nutrition Examination Survey, 2005 to 2011. The median serum ferritin concentration was 98.82 ng/mL for males and 38.60 ng/mL for females (P < 0.001). ⋯ Insulin resistance indices and abdominal obesity (trunk fat mass/percent) increased across the ferritin concentration quartiles after adjustment for confounders in males and females (P ≤ 0.011 for trend), and the risk of MetS increased across the ferritin quartiles in males (P < 0.001 for trend) and females (P = 0.001 for trend). The highest serum ferritin quartile exhibited a 1.62-fold increased risk of MetS (95% CI, 1.28-2.12) in males and a 1.36-fold increased risk of MetS (95% CI, 1.09-1.69) in females compared with the lowest quartile after adjustment for confounders. Our results suggest that ferritin is associated with insulin resistance and abdominal obesity.
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Comparative Study Observational Study
Can tranexamic acid reduce blood loss in cervical laminectomy with lateral mass screw fixation and bone grafting: a retrospective observational study.
To assess the safety and efficacy of tranexamic acid (TXA) for decreasing perioperative blood loss in cervical laminectomy with lateral mass screw fixation and bone grafting (CLF), in which all surgical procedures are identical. From November 2014 to April 2016, we performed a retrospective comparative analysis of 119 patients with multilevel cervical spondylotic myelopathy who had undergone a CLF from C3 to C6 in our center. All surgeries were performed on the patients using a consistent, standard procedure. ⋯ Total blood loss in the TXA group (287.74 ± 115.40 mL) was also significantly lower than that of the control group (401.96 ± 127.88, P < 0.01). No major intraoperative complications occurred in any of the cases. TXA significantly reduced perioperative blood loss in CLF with no major side effects.
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We aimed to establish a new formula for estimating renal depth, based on anthropometric variables, and to compare the estimates with actual data from a group of living kidney donors undergoing computed tomography angiography (CTA). Renal depths in 167 living kidney donors were measured by CTA. Regression analysis was used to derive the formulae for estimation of renal depth of both kidneys based on patient age, sex, body height, body weight, and body mass index (BMI). ⋯ The correlation coefficients between our left or right renal depth estimates and those obtained from other formulae in another 271 kidney donors were 0.864 (left) or 0.893 (right) by the Tønnesen, 0.937 (left) or 0.97 (right) by the Taylor, 0.937 (left) or 0.97 (right) by the Itoh, 0.927 (left) or 0.951 (right) by the Li-qian, and 0.937 (left) or 0.97 (right) by the Inoue formula. Our formula may be more precise than the Tønnesen formula in estimating the renal depth. Estimating formulae based on CT findings might be useful in clinical practice.
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The effectiveness of surgical pleth index (SPI) for managing nociception-antinociception balance during general anesthesia with vasodilators, including nicardipine has not been demonstrated. We aimed to compare the time course during surgery in SPI values in patients receiving nicardipine or remifentanil infusion during thyroidectomy. ⋯ This trial was registered in the UMIN clinical trials registry (unique trial number: UMIN000019058; registration number: R000022028; principal investigator's name: Young Ju Won; date of registration: September 17, 2015).