Medicine
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Red man syndrome (RMS) is the most common allergic reaction to vancomycin. It generally occurs during rapid infusion of vancomycin; only few cases have been reported as results of local vancomycin administration. We hereby report a rare case where RMS developed after insertion of vancomycin-loaded bone cement in a primary total knee replacement (TKR). ⋯ Vancomycin-induced RMS may occur after the routine use of vancomycin-loaded bone cement in the primary TKR replacement.
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Case Reports
Case report of a novel PCDH19 frameshift mutation in a girl with epilepsy and mental retardation limited to females.
Epilepsy with mental retardation limited to females (EFMR) is a rare type of X-linked epilepsy disorder, affecting heterozygous females disproportionately. The pathogenesis of EFMR has been identified as mutations in the protocadherin 19 (PCDH19) gene. To data, more than 60 different mutations in PCDH19 have been identified. Most of them are located at exon 1, but we describe a novel deletion mutation c.2468delT at exon 3 of PCDH19. ⋯ This case report describes a novel PCDH19 gene mutation (c.2468delT) at exon 3 in a girl suffering from EFMR. The deletion mutation was predicted to cause a frameshift mutation-p.L823fs, which is highly conserved across different species.
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Case Reports
Diagnosis and treatment of the pharyngeal glial choristoma accompanied with incomplete cleft palate: A case report.
A choristoma formed by heterotopic tissue rarely occurs in the throat, especially one accompanied with cleft palate in a new-born baby. ⋯ Choristoma rarely occurs in the head and neck, especially if accompanied by cleft palate. Early diagnosis for choristoma relies heavily on clinical examination and radiological imaging. Complete resection of choristoma remains the gold standard for treatment of these patients.
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A few studies using diffusion tensor tractography (DTT) have demonstrated recovery of injured corticoreticulospinal tract (CRT) in patients with intracerebral hemorrhage and infarct. However, no study reported on a patient who showed peri-infarct reorganization of an injured CRT following a middle cerebral artery territory infarct. ⋯ The recovery process of injured CRTs concurrent with recovery of leg weakness was demonstrated in a patient with SAH using DTT. This study has important implications in terms of regaining gait function by the recovery of bilaterally injured CRTs which was facilitated by the long-term rehabilitation.
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There is widespread obesity paradox in cardiovascular diseases, the cardiovascular influence from weight management remains controversial. Moreover, previous publications indicating that different weight reduction extent might lead to various results. Thus, it is of importance to reassess the cardiovascular benefits of weight management strategies. ⋯ The results of this systematic review could provide reliable and concrete evidence for weight loss and its cardiovascular benefits.Prospero registration number: CRD42018108582.