Medicine
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Meta Analysis
Diabetes mellitus increases the risk of hospital mortality in patients with Covid-19: Systematic review with meta-analysis.
The mortality rate associated with Covid-19 varies considerably among studies and determinants of this variability are not well characterized. ⋯ In a meta-analysis of hospitalized patients in China with a diagnosis of Covid-19, the mortality rate was 9.9% and a higher diabetes mellitus prevalence was independently associated with a worse prognosis. The independent influence of diabetes mellitus with Covid-19 mortality should be viewed as hypothesis-generating and warrants further study.
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Meta Analysis
Relationship of miRNA-146a to systemic lupus erythematosus: A PRISMA-compliant meta-analysis.
miRNA-146a is a microRNA that plays an important role in systemic lupus erythematosus (SLE). Several studies have examined the role of miRNA-146a in SLE, but have demonstrated equivocal or even contradictory conclusions. Therefore, this meta-analysis aimed to assess the role of miRNA-146a in SLE by examining data from previous studies. ⋯ PROSPERO CRD42019151381.
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Cancer patients are associated with a series of long lasting and stressful treatments and experiencing, and case management (CM) has been widely used and developed with the aim to increase the quality of treatments and improve the patient care services. The purpose of this review is to identify and synthesize the evidence of randomized controlled trial studies to prove that case management could be one way to address the quality of life of cancer patients. ⋯ There is some evidence that case management can be effective in cancer patients quality of life. However, due to the heterogeneity in the target population, measurement tools, and results applied, no conclusion can be made from a meta-analysis on the present bias. More rigorously multi-centered randomized controlled studies should be provided with detailed information about intervention in future research.
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Meta Analysis
MTHFR polymorphisms (rs1801133) and systemic lupus erythematosus risk: A meta-analysis.
The relationship between MTHFR (5, 10-methylene tetrahydrofolate reductase) gene polymorphisms and Systemic Lupus Erythematosus (SLE) has been wildly studied, but the results are still conflicting. Therefore, the purpose of this meta and pooled analysis was to identify the role of the MTHFR SNP (single nucleotide polymorphism, rs1801133) in SLE in a large sample of subjects and to assess the risk of SLE. ⋯ This cumulative meta-analysis showed that the MTHFR SNP (rs1801133) contributed to susceptibility of SLE. However, more multicentre well-designed case-control studies and larger sample sizes are exceedingly required to validate our findings in the future.
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Randomized Controlled Trial
Gestational diabetes mellitus in women increased the risk of neonatal infection via inflammation and autophagy in the placenta.
Gestational diabetes mellitus (GDM) produces numerous problems for maternal and fetal outcomes. However, the precise molecular mechanisms of GDM are not clear. ⋯ Our results suggest that women with GDM exhibit an increased risk of neonatal infection via inflammation and autophagy in the placenta.