Medicine
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Review Case Reports
5-Fluorouracil and actinomycin D lead to erythema multiforme drug eruption in chemotherapy of invasive mole: Case report and literature review.
5-Fluorouracil (5-FU) and actinomycin D (ActD) are often used in chemotherapy for various cancers. Side effects are more common in bone marrow suppression, liver function impairment, and gastrointestinal responses. Skin effects are rare and easy to be ignored by doctors and patients, which can lead to life-threatening consequence. ⋯ Delays in diagnosis or treatment may lead to serious consequence. We should pay attention to the dosage of 5-FU and ActD, monitor adverse reactions strictly, to reduce occurrence of skin malignant events.
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Hepatocellular carcinoma (HCC) is a liver cancer. In contrast, ferroptosis is a novel iron-dependent and ROS reliant type of cell death that is observed under various disease conditions. ⋯ RNA sequencing data from HCC patients were downloaded from The Cancer Genome Atlas (TCGA) database. Ferroptosis-related long non-coding RNAs (lncRNAs) were screened by Pearson correlation analysis. Patients were randomized into training or testing sets in a 1:1 ratio. They were constructed in the training set using univariate-Lasso and multivariate Cox regression analysis and further tested for prognostic values in the testing set. Four lncRNAs were identified. Kaplan-Meier analysis showed that patients in the high-risk group had a worse prognosis than those in the low-risk group. Following differentially expressed genes analysis of these two groups. Functional analysis showed association with oxidative stress response. Cox regression analyses showed that risk score was an independent prognostic indicator. Receiver operating characteristic curve (ROC) and decision curve analysis demonstrated the accuracy of prediction. Four ferroptosis-related lncRNAs based on differential expression of HCC were screened by bioinformatic methods to construct a prognostic risk model and accurately predict the prognosis of HCC patients. Four lncRNAs may have a potential role in the anti-tumor immune process and serve as therapeutic targets for HCC. To lay the foundation for subsequent studies.
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Randomized Controlled Trial
Effects of esketamine on analgesia and postpartum depression after cesarean section: A randomized, double-blinded controlled trial.
The aim of this randomized double-blind placebo controlled clinical trial was to investigate the effects of different doses of esketamine combined with sufentanil for postoperative intravenous controlled analgesia after cesarean section and the incidence of postpartum depression. ⋯ Esketamine combined with sufentanil used for patient controlled intravenous analgesia after elective cesarean section can reduce the consumption of sufentanil, improve postoperative analgesia, decrease the incidence of PPD at 1 week and 6 weeks and postoperative nausea and vomiting.
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The purpose of this study was to perform a meta-analysis comparing the oncological, intraoperative and safety outcomes in laparoscopic rectal cancer surgery with and without preservation of the left colic artery (LCA). ⋯ The available evidence suggests that preserving the left colic artery is a safe, effective technique for patients with laparoscopic rectal cancer. nique for patients with laparoscopic rectal cancer.
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Meta Analysis
Chinese herbal bath therapy for the treatment of Atopic dermatitis in children: A meta-analysis and systematic review.
To conduct a systematic review of the efficacy of Chinese herbal bath therapy on children with Atopic dermatitis. ⋯ The present study shows that Chinese herbal bath therapy is an effective treatment for children with Atopic dermatitis in China.