Medicine
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The study was aimed to analyze the potential gene modules and hub genes of Duchenne muscular dystrophy (DMD) by weighted gene co-expression network analysis. ⋯ SERPING1, F13A1, C1S, C1R, and HLA-DPA1 may participate in the development of DMD by regulating innate immunity and inflammation, and they are expected to be a potential biomarker and novel therapeutic targets for DMD.
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Lumbar disc herniation (LDH) is a common orthopedic disease, which is one of the main causes of global chronic pain and motor function defect. For intractable LDH, the surgical treatment of percutaneous transforaminal endoscopic discectomy (PTED) is often used in clinical practice. Although the operation is relatively mature, there may still be some limitations and surgical risks delaying the recovery process of patients. Some studies have found that the combination of acupuncture therapy and PTED can bring more benefits to patients, but these conclusions are still lack of evidence support. Therefore, this study will adopt the method of meta-analysis to estimate the effectiveness and safety of acupuncture combined with PTED in patients with LDH, in order to provide a basis for clinical decision-making. ⋯ This study can provide evidence support for acupuncture combined with PTED in the treatment of LDH.
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There is no evidence-based data to confirm the efficacy of Yiqi Huoxue Yangxin Decoction combined with Western medicine in patients with coronary heart disease (CHD). Therefore, in order to provide new medical evidence for clinical treatment, we used this protocol to conduct a systematic review and meta-analysis on the effectiveness and safety of Yiqi Huoxue Yangxin Decoction combined with Western medicine in patients with CHD. ⋯ The results of our review will be reported strictly following the PRISMA criteria and the review will add to the existing literature by showing compelling evidence and improved guidance in clinic settings.
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Postsurgical gastroparesis syndrome (PGS) is an early common complication after upper abdominal surgery, especially which occurs mainly after gastroduodenal operation. Acupuncture, a complementary and alternative therapy, has been widely used in China because of its significant effect and few side effects. We conduct a protocol for systematic review and meta-analysis to assess the efficacy and safety of acupuncture for the treatment of PGS. ⋯ The conclusion of this review will provide evidence to judge whether acupuncture is an effective intervention for patient with PGS.