Medicine
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Randomized Controlled Trial
Application of dural puncture epidural technique combined with programmed intermittent epidural bolus mode in labor analgesia: A randomized clinical trial.
This study aims to evaluate the onset, maintenance, side effects s and the effect on newborns of dural puncture epidural (DPE) technique combined with programmed intermittent epidural bolus (PIEB) mode for labor analgesia as compared to conventional epidural (EP) technique combined with continuous epidural infusion (CEI) mode. ⋯ DPE technique can provide faster analgesia than conventional EP technique, combined with PIEB mode maybe superior to traditional methods as a labor analgesia regimen.
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Randomized Controlled Trial
Life quality improvement of patients with non-small cell lung cancer undergoing targeted therapy: A case study of continuous care.
To investigate the improvement effect of targeted therapy on non-small cell carcinoma patients life quality after the continuous nursing intervention. 104 non-small cell lung cancer patients in our hospital from July 2017 to November 2019 were allocated evenly and randomly into the control group (C) and the study group (S). By using clinical baseline data, quality of life questionnaire core 30 for cancer patients, evaluation of patient compliance behavior, the MOS item short-form health survey (SF-36), self rating depression scale (SDS), self rating anxiety scale (SAS), Overall Survival (OS) progression-free survival and adverse reaction symptoms were evaluated for the life quality of patients. There was comparability between the 2 sets of basic data. ⋯ Taking a 2-year follow-up period as an example, significant statistical differences existed in OS and progression-free survival rates between adenocarcinoma and squamous carcinoma. SDS and SAS had high consistency in scoring with QLQ-30 and SF-36 scales. Targeted treatment for non-small cell carcinoma patients significantly improves their life quality and reduces the incidence of adverse reactions after continuous nursing intervention.
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Randomized Controlled Trial
Safety and effectiveness of endotracheal intubation in critically ill emergency patients with videolaryngoscopy.
To investigate the safety and efficacy of video laryngoscopy for endotracheal intubation in critically ill patients. A total of 106 critically ill emergency patients treated at our hospital between January 2021 and June 2022 were randomly divided into 2 groups, the visual and direct groups, with 53 patients in each group. Both groups were treated with endotracheal intubation; the visual group was treated with video laryngoscopy, and the direct group was treated with conventional direct laryngoscopy. ⋯ Endotracheal intubation under videolaryngoscopy is safer and more effective for critically ill emergency patients than conventional direct laryngoscopy. This can improve the success rate of intubation, reduce the intubation time, and reduce its effect on hemodynamics. Therefore, it is worthy of further clinical application.
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Review Case Reports
A neonatal case report of branchiooculofacial syndrome caused by a novel mutation in the TFAP2A gene and literature review.
Branchiooculofacial syndrome (BOFS) is a rare autosomal dominant disorder with a diverse clinical phenotype. To summarise the clinical characteristics and genetic variations of neonatal-onset BOFS through a case study and literature review. ⋯ The characteristic facial features, branchial skin defects, and ocular anomalies are the main clinical manifestations of BOFS with neonatal onset, but the diverse clinical phenotype and variable genetic variants pose certain challenges for clinical diagnosis.
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Postoperative pulmonary complications (PPCs) increase postoperative mortality, hospital stays, and healthcare costs. Whether the use of sugammadex could reduce PPCs remains controversial. This study aimed to determine if sugammadex could more effectively reduce PPCs than acetylcholinesterase inhibitor (AChEi) in patients who had undergone spine surgery, in prone position intraoperatively. ⋯ Respiratory failure occurred in 7 (4.9%) patients in the Sugammadex group and 5 (3.5%) patients in the AChEi group (P = .77). There was no significant difference in secondary outcomes between the 2 groups. Although there have been some evidences showing that the use of sugammadex can attenuate the development of PPCs, this study did not show positive effects of sugammadex on patients who underwent spine surgery in the prone position.