Medicine
-
Herpes zoster (HZ) is an infection caused by the varicella-zoster virus reactivation, often leading to peripheral nervous system infection and pain. This case report aimed to present 2 patients with damaged sensory nerves originating from the visceral neurons of the lateral horn of the spinal cord. ⋯ Herpetic visceral neuralgia can be easily misdiagnosed due to the absence of a rash or herpes, resulting in delayed treatment. When patients have severe, intractable pain but no rash or herpes, and the biochemical and imaging examinations are normal, the treatment method for HZ neuralgia can be used. If the treatment is effective, HZ neuralgia is diagnosed. If not, shingles neuralgia can be ruled out. Further investigations are required to elucidate the mechanisms of pathophysiological changes in varicella-zoster virus-induced peripheral HZ neuralgia or visceral neuralgia without herpes.
-
Osteoarthritis (OA) is a common joint disease that mainly damages articular cartilage and involves the whole joint tissue. The purpose of this study was to explore the relationship between F2R Like Thrombin Or Trypsin Receptor 3 (F2RL3) and OA, so as to provide a new direction for the treatment of bone and joint. A total of 234 patients with OA were recruited. ⋯ Pearson chi-square test showed that F2RL3 (P < .001) was significantly associated with OA; Spearman correlation coefficient showed that OA and F2RL3 (ρ = -0.511, P < .001) significantly correlated; Univariate Logistic regression analysis showed that F2RL3 (odds ratio = 0.104, 95% confidence interval: 0.057-0.189, P < .001) was significantly associated with OA; multivariate logistic regression analysis showed that F2RL3 (odds ratio = 0.098, 95% confidence interval: 0.053-0.182, P < .001) were significantly associated with OA. The expression of F2RL3 is low in patients with OA. The lower the expression of F2RL3, the higher the probability of OA.
-
Intraductal papillary mucinous neoplasms (IPMN) of the accessory pancreatic duct (APD) are very rare and their clinical significance is not known. Here, we describe a case of IPMN originating in a branch of the duct of APD within the uncinate process of the pancreas, which initially presented with acute pancreatitis. ⋯ APD-IPMN in the pancreas uncinate process has its own characteristics of localized pancreatitis, and MD-preserving DPPHR-P not only protects the exocrine and endocrine functions of the pancreas, but it also protects the physiological and anatomical integrity. The appearance of POPF after DPPHR-P may be managed by endoscopic pancreatic duct stenting.
-
Meta Analysis
The efficacy of vericiguat for heart failure: A meta-analysis of randomized controlled trials.
The efficacy of vericiguat was elusive for heart failure. This meta-analysis aimed to explore the efficacy of vericiguat for heart failure. ⋯ Vericiguat treatment may benefit to treat heart failure.
-
Meta Analysis
Diagnostic accuracy of circulating exosomal circRNAs in malignances: A meta-analysis and systematic review.
Pathogenesis of malignant tumors are often accompanied by aberrant expression of circular RNAs (circRNAs), indicating the potential diagnostic value of circRNAs in tumors. CircRNAs have been found to be enriched, stable and ubiquitous in serum and plasma exosomes. The study aims at evaluating the diagnostic performance of circulating (plasma and serum) exosomal circRNA in different types of cancer by synthesis of published data. ⋯ In conclusion, our study evaluated the diagnostic power of circulating exosomal circRNAs in 6 types of cancer by synthesis of published data comprising 21 studies from eleven articles. The pooled analysis provided the evidence supporting circulating exosomal circRNAs as a promising noninvasive diagnostic biomarkers for malignancies.