Medicine
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Epidemiological research has demonstrated that people suffering from ankylosing spondylitis (AS) have a greater chance of developing cardiovascular disease (CVD), though the potential link between AS genetics and CVD risk is uncertain. This research examined the potential link between CVD outcomes and AS which is genetically determined. A two-sample Mendelian randomization analysis was conducted using data from European population genome-wide association study of AS and CVD. ⋯ A sensitivity analysis was conducted to validate the reliability of the results. Evidence from the European population has indicated a correlation between AS and heart failure, hypertension, and ischemic stroke. Further investigations should be conducted to explore the underlying mechanisms of action.
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Digital management on sport (DMS) has become a hot topic around sports management. However, a more comprehensive and in-depth investigation into the structure and progression of this field is necessary. We used CiteSpace software to conduct a bibliometric analysis, revealing dynamic patterns in the evolution of co-citation, collaboration, and keyword co-occurrence within this field. ⋯ Since 2018, the growth in publications on DMS reflects increasing academic interest. Australia's institutions lead in collaboration, though international cooperation is limited. High co-citation authors hold significant influence and research focuses on management, social media, and physical activity.
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The neutrophil-to-lymphocyte ratio (NLR) is an important inflammatory marker. However, the relationship between NLR and the prognosis of patients with coronary heart disease (CHD) remains unclear. The purpose of this study is to explore the relationship between NLR and all-cause mortality and cardiovascular mortality in CHD patients. ⋯ The results of the restricted cubic spline analysis indicated a nonlinear relationship between NLR and all-cause mortality as well as cardiovascular mortality in CHD patients. In addition, receiver operating characteristic analysis showed that the area under the curve for all-cause mortality at 3 years, 5 years, and 10 years were 0.596, 0.591, and 0.604, while the area under the curve for cardiovascular mortality were 0.623, 0.617, and 0.623, in CHD patients. Elevated NLR is associated with increased risk of cardiovascular and all-cause mortality in CHD patients, and NLR can independently predict the prognosis of CHD patients.
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With the exacerbation of population aging in China, policies have been formulated to provide elderly medical care resources. However, research on the matching situation of these resources with the elderly population (EP) is relatively scarce. This study collected data on elderly medical care resources and the EP from various provinces in mainland China from 2011 to 2017. ⋯ The matching degree between elderly medical care resources and the EP in China urgently needs to be improved. Economic conditions have a significant impact on the matching degree. To better serve the EP, it is needed to increase investments in elderly medical care resources in the western and northeastern regions, and promote an increase in the matching degree by enhancing per capita gross domestic product and fiscal health expenditure.
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At present, the association of smoking, alcohol intake, and coffee intake with the risk of bacterial pneumonia (BP) remains controversial. In this study, we used a 2-sample Mendelian randomization (MR) analysis to estimate the association of smoking, alcohol intake, and coffee intake with the risk of BP. ⋯ Our findings provide relevant evidence for a favorable causal association of genetically predicted smoking initiation and cigarettes per day with BP risk. However, there may not be a causal association between past tobacco smoking, alcohol intake, and coffee intake with increased BP incidence rates.