Medicine
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Meta Analysis
Acute myeloid leukemia treatment outcomes with isocitrate dehydrogenase mutations: A systematic review and meta-analysis.
Isocitrate dehydrogenase (IDH) gene alterations and acute myeloid leukemia (AML) treatment results remain controversial. This study reviews the literature on IDH mutations in AML to determine the foundation of individualized therapy and improve effectiveness, survival time, and recurrence rate. ⋯ Different subtypes of IDH mutations may lead to different AML prognoses, suggesting the feasibility of personalized treatment for AML patients.
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Gliomas are tumors arising in the central nervous system, frequently associated with Class I mutations and BRAF fusions. These mutations are adverse prognostic factors in juvenile gliomas, leading to high rates of recurrence and poor response to current treatments. The blood-brain barrier and the heterogeneity of gliomas complicate the development of a single treatment strategy for all cases. ⋯ However, challenges remain in managing side effects such as fever, headache, lethargy, and rash. Further research into resistance mechanisms and long-term effects is necessary to optimize treatment strategies. Other therapies, such as everolimus and Selumetinib, also show potential and warrant further investigation.
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Malaria has posed a momentous health and economic burden to the Sub-Saharan African region. The Sub-Saharan African region accounts for more than 90% of global malaria-related mortality and morbidity. Pregnant women and children under 5 years old are the most vulnerable. ⋯ Despite the aforementioned strategies, the pervasiveness of malaria infection in the Sub-Saharan African region is worrisome. Thus, strengthening the already existing control measures, finding novel measures through intensive research, and embracing malaria vaccination could help accelerate the overcoming of this scuffle. In this review, we utilized relevant published data from various databases to reexamine the factors fueling malaria pervasiveness in this region and spelled out point-by-point intervention protocols to end malaria scuffle.
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Review
Resilience: A panacea for burnout in medical students during clinical training?: A narrative review.
Clinical rotations or clerkships are a necessary part of medical education but are associated with significant psychiatric morbidity, including burnout and psychological distress. This review aims to explore the role of resilience as a protective factor and assess the effectiveness of resilience-building interventions. We conducted a narrative review using the Medline database via PubMed. ⋯ Interventions such as psychological workshops and curriculum changes showed mixed results, with competence-based approaches showing the most promise for long-term benefits. Resilience is a critical target for improving medical students' psychological health and reducing burnout during clinical training. Future interventions should focus on combining psychological support with competence-based training to equip students for the challenges ahead.
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Randomized Controlled Trial Comparative Study
Efficacy of generic versus branded diacerein for treatment of knee osteoarthritis: A randomized control trial.
Several studies have proved that diacerein effectively treats knee osteoarthritis (OA). All studies used branded diacerein. Recently, generic diacerein has been available in several countries, with limited studies comparing the efficacy of generic and branded diacerein for knee OA treatment. ⋯ After a 24-week FU, the generic diacerein had similar efficacy as the branded diacerein in significantly improving VAS and PBMs: 5 × SST and 3MWT. However, the latter had a faster statistically improved VAS than the former.