Medicine
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Comparative Study
Comparison of chromosomal microarray and karyotyping in prenatal diagnosis using 491 amniotic fluid samples.
This study was aimed to investigate the performance of chromosomal microarray analysis (CMA) in prenatal diagnosis compared with traditional karyotyping analysis. Both CMA and karyotyping analyses were performed to detect the karyotypes in the amniotic fluid of 491 pregnant women who got prenatal diagnosis at the Center of Prenatal Diagnosis of Shangrao (China) during January 2019 to April 2021. After excluding 2 samples in the CMA analysis and 2 samples in the karyotyping analysis which were failed in detection, the remaining 487 amniotic fluid samples were detected. ⋯ Furthermore, 23 cases of copy number variation (CNVs) with variation of unknown clinical significance (VOUS) were detected by CMA, which accounted for 4.68% (23/491) in all cases. However, CMA was not able to accurately identify some complex karyotypes and mixed chimeras, including 2 cases of chimeras, 4 cases of balanced translocations, 4 cases of pericentric inversions, and 8 cases of other chromosome polymorphisms, indicating karyotyping analysis was superior to detect these chromosome abnormalities compared with CMA analysis. CMA was better in detecting the fracture sites, microduplication and microdeletion with definite pathogenicity, and CNVs with VOUS compared with karyotype analysis.
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Observational Study
Procalcitonin, C-reactive protein, and white blood cell count levels in end-stage cancer patients: A retrospective study on inflammatory markers and their prognostic value.
Procalcitonin (PCT), C-reactive protein (CRP), and white blood cell count (WBC) are commonly recognized as inflammatory markers. Some studies showed that these markers were also related to some cancers. This study aimed to investigate whether these markers were exhibited aberrations in end-stage cancer patients and to assess their correlation with infection and prognosis. ⋯ The PCT, WBC, and CRP levels of end-stage cancer patients were significantly elevated, regardless of infection. An increase in PCT and WBC was associated with an increased risk of death. These findings suggest that monitoring PCT and WBC levels in end-stage cancer patients may provide valuable prognostic information, aiding in clinical decision-making.
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Observational Study
Association of red blood cell distribution width-albumin ratio with in-hospital mortality in abdominal aortic aneurysm patients.
To explore whether red blood cell distribution width-albumin ratio (RAR) is relevant to in-hospital mortality among abdominal aortic aneurysm (AAA). This is a retrospective study retrieving data from the MIMIC-IV database. Patients were divided into survivor or non-survivor groups by the in-hospital mortality. ⋯ Finally, the length of hospital stay and ICU stay were longer in the RAR ≥ 4.658 group (P < .05). RAR is a potential risk predictor for in-hospital mortality in AAA patients. Further, RAR upregulation was significantly correlated with prolonged length of hospital stay and ICU stay.
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Observational Study
Impact of COVID-19 on acute angle-closure attack: A retrospective study.
To systematically review the characteristics of patients experiencing acute angle closure (AAC) attacks during the COVID-19 outbreak in Beijing. Patients with AAC attacks during the COVID-19 epidemic and those in the same period the following year were recruited. Demographic characteristics, ocular biometry, ocular signs, sequential relationships, and the prognosis of operative management outcome were recorded and compared between the 2 groups. ⋯ Most patients had an ideal prognosis after comprehensive management. An increased incidence of AAC attacks, more bilateral cases and severe anterior segment inflammation were observed during the COVID-19 outbreak in Beijing. There may be a correlation between the onset of AAC attacks and coronavirus infection, but further research is needed to explore this link.
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A systematic retrospective analysis of patients with lumbar disc herniation treated with percutaneous endoscopic discectomy was performed to identify key risk factors for postoperative recurrence, and a Nomogram prediction model was constructed based on them. The data of patients with lumbar disc herniation who were treated in our hospital between January 2021 and December 2023 were included in this study. Statistical tools, including univariate and multivariate logistic regression analyses, were used to accurately screen independent risk factors significantly associated with postoperative recurrence. ⋯ The model performance was evaluated by plotting the receiver operating characteristic curve and calculating the area under the curve, supplemented by calibration curve and decision curve analysis, to ensure the predictive accuracy and clinical practicability of the model. 286 patients with lumbar disc herniation were included in the study, and 29 patients had a postoperative recurrence, with a recurrence rate of 10.14%. After univariate and multivariate logistic regression analyses, a total of 5 variables were identified as independent risk factors for postoperative recurrence of lumbar disc herniation: age > 60 years (OR = 2.831; 95% CI = 1.089-5.430), body mass index (BMI) > 24 kg/m2 (OR = 4.632; 95% CI = 1.183-14.337), The type of lumbar disc herniation was herniation (OR = 5.064; 95% CI = 1.198-15.364), degeneration grade III-IV (OR = 5.916; 95% CI = 1.357-16.776), and postoperative high-intensity activity (OR = 4.731; 95% CI = 1.341-14.024). The nomogram constructed in this study for postoperative recurrence of lumbar disc herniation by percutaneous endoscopic discectomy has good predictive accuracy, and this tool can effectively assist orthopedic surgeons in identifying high-risk patients with recurrence after percutaneous endoscopic discectomy, providing a scientific basis for early intervention and individualized management strategies, thus optimizing patient prognosis.