Medicine
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The aim of this study is to explore the current study status and progression of the effects of ropivacaine in local analgesia by using bibliometric methods. ⋯ The application of ropivacaine to postoperative anesthesia attracts growing interest from the scholars all over the world and was the future research hotspot in treating postoperative pain.
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Preventive treatment is crucial in averting the onset of musculoskeletal diseases, particularly among individuals in high-stress occupations. This study aimed to develop a forest healing program and a standardized survey index to gauge its efficacy in mitigating stress and preventing musculoskeletal disorders. Service-oriented workers who engage in repetitive tasks but are not traditional office workers at risk of musculoskeletal issues were recruited. ⋯ Evaluation of 42 participants pre- and post-program revealed significant reductions in PSS (25.857 ± 8.120/17.905 ± 5.958; P < .001), SOM (27.905 ± 8.839/20.286 ± 8.019; P < .001), and standard survey index scores (33.857 ± 10.280/23.333 ± 8.703; P < .001). The developed forest healing program demonstrated substantial stress relief and muscle relaxation benefits, proving effective in preventing musculoskeletal diseases. Moreover, the standardized survey index emerged as a valuable tool for assessing stress related to such disorders, exhibiting correlations with PSS and SOM.
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To analyze the current status, hotspots, and cutting-edge trends of PM2.5 health effects of PM2.5, using CiteSpace. ⋯ The findings of this bibliometric analysis offer insight into the status and direction of research on PM2.5 and its health impacts, which aid scientists in coming up with new directions for their investigation.
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Endometrial cancer (EC) is the most common gynecologic malignancy with increasing incidence and mortality. The tumor immune microenvironment significantly impacts cancer prognosis. Weighted Gene Co-Expression Network Analysis (WGCNA) is a systems biology approach that analyzes gene expression data to uncover gene co-expression networks and functional modules. ⋯ Basic leucine zipper activating transcription factor-like transcription factor(BATF) expression in EC tissues positively correlated with CD8+ T cell infiltration, suggesting BATF's crucial role in EC development and antitumor immunity. The prognostic model comprising ARPC1B, BATF, CCL2, and COTL1 can effectively identify high-risk EC patients and predict their response to immunotherapy, demonstrating significant clinical potential. These genes are implicated in EC development and immune infiltration, with BATF emerging as a potential therapeutic target for EC.
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Autophagy is a cellular process in which damaged organelles or unnecessary proteins are encapsulated into double-membrane structures and transported to lysosomes for degradation. Autophagy plays a crucial role in various liver diseases, including nonalcoholic fatty liver disease. This study aims to elucidate the role of autophagy in nonalcoholic fatty liver disease through bibliometric analysis. ⋯ Research on autophagy in nonalcoholic fatty liver disease is still in its early stages, with a growing body of literature. This study is the first to provide a comprehensive bibliometric analysis, synthesizing research trends and advancements. It identifies current development trends, global cooperation models, foundational knowledge, research hotspots, and emerging frontiers in the field.