Medicine
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Multicenter Study Observational Study
Relevance of oxidative stress for small intestinal injuries induced by nonsteroidal anti-inflammatory drugs: A multicenter prospective study.
Several reports revealed that oxidative stress was involved in the mouse model of nonsteroidal anti-inflammatory drug (NSAIDs)-induced small intestinal mucosal injuries. Thus, we aimed to investigate in the prospective clinical study, that the relevance of oxidative stress balance in small intestinal mucosal injury in NSAIDs users. We prospectively included 60 patients who had been taking NSAIDs continuously for more than 3 months and exhibited obscure gastrointestinal bleeding (number UMIN 000011775). ⋯ In aspirin users, d-ROM and OXY levels did not differ significantly with respect to mucosal injuries or ulcers. However, in nonaspirin users, OXY level was significantly lower in the mucosal injury group (P = .04), and d-ROM levels were significantly higher in the ulcer group (P = .02). Nonaspirin NSAIDs-induced intestinal mucosal injury is associated with antioxidant systems, resulting in increased oxidative stress.
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Randomized Controlled Trial
The effects of common peroneal nerve electrical stimulation on lower extremity deep venous hemodynamics: A randomized, crossover and controlled study.
Intermittent pneumatic compression (IPC) and neuromuscular electrical stimulation can improve deep vein hemodynamics in the lower limbs. We developed a new, small and convenient, and easy to wear common peroneal nerve electrical stimulator (CPNES) and to investigate the effectiveness and safety of CPNES intervention on deep venous hemodynamics. ⋯ The effectiveness of CPNES intervention on the hemodynamics of the lower extremity is similar with that of IPC, increasing blood flow and may prevent venous thrombosis without adverse reaction.
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Randomized Controlled Trial
The impact of the "treasure game" on geometric thinking and post-learning mood in first-grade children.
This study aimed to investigate the effect of the motor game "Treasure Game" (TG) on first-grade children's level of geometric thinking and post-learning mood tracking (PLMT). ⋯ The study confirms that participation in the TG significantly enhances GT and improves post-learning mood in first-grade children. This suggests that integrating motor activities like TG into the curriculum could be a viable strategy for enhancing early geometric education. Further research with larger sample sizes and considerations of gender differences is recommended.
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Randomized Controlled Trial
Quantification of gait characteristics and muscle activation in patients with chronic ankle instability during walking on sand: A randomized crossover trial.
Limited evidence exists regarding the movement control patterns of individuals with chronic ankle instability (CAI) during sand walking. This study aimed to analyze gait characteristics and muscle activation in patients with CAI while walking on sand. ⋯ These results suggest that sand can influence gait characteristics and muscle activation in patients with CAI. Our findings indicate that gait characteristics and muscle activation changes in patients with CAI could potentially benefit CAI rehabilitation.
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Randomized Controlled Trial
Use of continuous infusion technique with pre-filled elastic pumps for prevention of centrally inserted central catheter occlusion in critically ill patients: A feasibility study.
Flushing catheter seems to be a crucial procedure for preventing centrally inserted central catheter (CICC) occlusion, which can flush the liquid and blood attached to the lumen into the bloodstream. The continuous infusion technique is characterized by continuous perfusion of flushing fluid and maintaining positive pressure in the lumen, which has been demonstrated to effectively prevent peripheral indwelling needle occlusion. However, the use of continuous infusion technique in CICC care among critically ill patients has been rarely described. ⋯ In this study, continuous infusion technique with pre-filled elastic pumps was successfully used in critically ill patients for prevention of CICC occlusion, without major undesired effects. A larger cohort and a randomized clinical trial are warranted in order to establish its absolute efficacy in CICC care.