Medicine
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Cerebral amyloid angiopathy-related inflammation (CAA-ri) is a treatable condition characterized by an acute or subacute onset, with its primary pathological hallmark being the deposition of amyloid, predominantly β-amyloid (Aβ), within intracranial microvessels. Despite its potential for treatment, CAA-ri is a rare disorder that is frequently underrecognized by clinicians in practice. This article provides a comprehensive overview of the clinical manifestations and therapeutic approaches associated with CAA-ri, aiming to enhance awareness among healthcare professionals. ⋯ CAA-ri is a rare clinical condition, and timely diagnosis and early treatment are very critical for patient prognosis.
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Comparative Study Observational Study
Incidence of acute angle closure in patients with primary angle closure without prophylactic iridotomy during pharmacological mydriasis for cataract surgery.
The objective was to study the incidence of acute primary angle closure (acute PAC) during pharmacologic mydriasis before cataract surgery and changes in anterior chamber angle parameters in patients with primary angle closure diseases (PACD) with and without prophylaxis laser peripheral iridotomy (LPI). This was a prospective, comparative study of cataract patients with PACD with and without prophylaxis LPI presented at the Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand during June 2022 to December 2023. The incidence of acute PAC during pharmacologic mydriasis prior to cataract surgery was recorded. ⋯ There was no incidence of acute PAC in patients with and without prophylaxis LPI during pharmacological mydriasis in the preoperative preparation for cataract surgery. Eyes without LPI showed significantly lower preoperative anterior chamber angle parameters compared to eyes with previous LPI, but not significantly different postoperatively. The benefits of prophylactic LPI for PACD scheduled for cataract surgery must be further investigated.
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Case Reports
A case of posterior urethral valve diagnosed by ultrasound in antenatal and pathology: A case report.
Posterior urethral valve is a rare disease, prenatal diagnosis and prognosis evaluation are particularly important. ⋯ Prenatal ultrasonography can diagnose posterior urethral valve through typical image manifestations and can make a certain judgment for prognosis evaluation.
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Observational Study
Assessing the timing of amniotomy after Foley balloon catheter removal in women with labor induction: The role of Bishop score: An observational study.
The timing of amniotomy after the Foley balloon catheter removal is crucial for successful labor induction. This study aimed to assess the effects of the Bishop score on the timing of amniotomy in patients undergoing labor induction after the Foley balloon catheter removal. This was a retrospective cohort study based on electronic medical records. ⋯ The baseline data, operative vaginal delivery rate, postpartum hemorrhage rate, infection rate, thrombosis rate, intrapartum and postpartum hemorrhage volume, and neonatal outcomes showed no significant differences between the 2 groups. However, the cesarean delivery rate, interval from induction to delivery, and hemoglobin postdelivery decline were significantly decreased in the favorable Bishop score group. Amniotomy with a favorable Bishop score after Foley balloon catheter removal is linked to lower cesarean delivery rates, shorter induction-to-delivery intervals, and less postdelivery hemoglobin decline without increasing adverse maternal or neonatal outcomes.
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Dyslipidemia has been established as a potential risk factor for venous thromboembolism (VTE) in several observational studies. Statins and novel lipid-modifying agents are being explored for their potential in VTE prevention, encompassing deep vein thrombosis (DVT), and pulmonary embolism (PE). Nonetheless, conclusive evidence supporting the effectiveness remains uncertain. ⋯ Additionally, the inhibition of APOC3 was linked to a higher DVT risk (OR: 1.002, 95% CI: 1.000-1.004, P = .038). Research has shown that HMGCR, out of 8 lipid-lowering drug-targets evaluated, exhibited a significant correlation with VTE and LEDVT, highlighting its potential as an effective target for the treatment or prevention of these conditions. In contrast, APOB, LPL, and APOC3 each contribute to an increased risk of VTE, PE, and LEDVT in various degrees, pharmacovigilance for VTE, PE, and LEDVT risk among users of APOB inhibitors, LPL activation, and APOC3 inhibitors may be warranted.