Medicine
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In traditional medicine (TM), blood stasis syndrome (BSS) is characterized by insufficient blood flow, resulting in a group of symptoms such as fixed pain, a dark complexion, bleeding, and an astringent pulse. While BSS pathology has been previously explored, its molecular mechanisms remain elusive owing to challenges in linking TM symptoms to genes. Our study aimed to elucidate the mechanisms underlying BSS using a phenotype-genotype association approach. ⋯ Enrichment analysis indicated the involvement of BSS genes in the immune system (P-value = 4.49e-14) and hemostasis (P-value = 1.28e-07) pathways. BSS symptoms were linked to genes regulating blood coagulation, immune responses, blood flow, and inflammatory reactions. This approach may be extended to establish genotype networks for understanding TM pattern identifications, which are composed of diverse groups of symptoms, for personalized diagnosis and treatment.
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Observational Study
Construction and validation of a prediction model for acute ischemic stroke patients with concomitant deep vein thrombosis.
The aim was to investigate the independent risk factors for complications of deep vein thrombosis (DVT) in patients with acute ischemic stroke (AIS), and to establish a nomogram prediction model accordingly. The data of AIS patients in our hospital were collected from January 2021 to December 2023, and single-factor and multifactorial logistic regression analyses were used to determine the independent risk factors for the complication of DVT in patients with AIS and to establish the corresponding nomogram. ⋯ After univariate and multivariate logistic regression analyses, a total of 5 variables were identified as independent risk factors for the complication of DVT in patients with AIS: age > 70 years (OR, 1.551; 95% CI, 1.189-2.751), diabetes (OR, 2.543; 95% CI, 1.322-4.265), the national institutes of health stroke scale > 16 (OR, 3.124; 95% CI, 1.314-7.003), D-dimer > 0.5 mg/L (OR, 2.303; 95% CI, 1.250-3.645), and fibrinogen > 4 g/L (OR, 1.918; 95% CI, 1.532-6.369). The nomogram constructed in this study for AIS patients with concomitant DVT has good predictive accuracy and helps physicians to intervene in advance in patients at high risk of acute AIS patients with concomitant DVT.
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Chronic hepatitis (CH) refers to liver inflammation lasting at least 6 months caused by various factors, significantly impacting patients' daily lives. Paeoniae Radix Rubra (CS) is a classic blood-activating and stasis-dissolving herb known for its protective effects on the liver. This research seeks to investigate the underlying mechanisms by which CS treat CH, employing network pharmacology and molecular docking. ⋯ This research uncovers the possible mechanisms of CS in CH treatment, offering new avenues for future studies.
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Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is a group of life-threatening autoimmune small vessel vasculitis and the prognosis depends heavily on whether a prompt diagnosis is achieved. Autoimmune thyroiditis is the most common autoimmune endocrine disease and could overlap with other autoimmune diseases. It remains elusive whether autoimmune thyroiditis affects the risk of AAV development. ⋯ Mendelian randomization-Egger and the weighted median method were used to confirm the results. We found a causal association between Hashimoto thyroiditis and MPA while no causal effect of Grave disease on MPA. This study contributed a genetic viewpoint to the understanding of the link between autoimmune thyroiditis and AAV.
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Traditional observational studies have shown that fatty acids and gut microbiota are crucial in osteoarthritis (OA) progression, but their findings are often conflicting due to biases, confounding factors, and measurement errors. We conducted a two-sample Mendelian randomization analysis using genome-wide association study data on fatty acids from 136,016 individuals, the gut microbiota from 7738 individuals, and osteoarthritis from 314,870 individuals. ⋯ Conversely, Oscillibacter (OR: 1.16; 95% CI 1.00-1.34; P = .043), Bilophila (OR: 1.28; 95% CI 1.07-1.54; P = .007), Erysipelotrichaceae (OR: 1.08; 95% CI 1.00-1.16; P = .044), and Bilophila within the Desulfovibrionaceae family (OR: 1.19; 95% CI 1.04-1.36; P = .012) were associated with an increased risk of OA. The findings indicate that modulating dietary factors and gut microbiota can independently reduce the risk and progression of OA, potentially improving the quality of life and health management in aging populations.