Medicine
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Immune reconstitution is a significant factor in the success of "hematopoietic stem cell transplantation" (HSCT). Delaying the immune reconstitution increases the risk of infections and relapse after transplantation. T-cell recovery after HSCT is mainly thymus-dependent, and thymic atrophy is associated with various clinical conditions that correlate with HSCT outcomes. Thymus rejuvenation can improve immune reconstitution after transplantation.Zinc (Zn) plays a pivotal role in thymus rejuvenation. Zn deficiency can lead to thymic atrophy, which increases susceptibility to infections. Zn supplementation restores the immune system by increasing thymus output and T-cell repertoire production.We designed this protocol to investigate the effect of oral Zn supplementation on T-cell recovery in patients undergoing HSCT. ⋯ This clinical trial is the first to determine the efficiency of "Zn gluconate" as daily Supplementation in T cell recovery post-HSCT.If successful, an available and inexpensive drug will improve immune system reconstruction after HSCT, reduce the risk of infection, particularly viral infections, and increase patient survival.
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Although observational studies have revealed a link between frailty and serum micronutrient levels, it remains unclear whether these 2 states are directly connected. Thus, Mendelian randomization (MR) was used to investigate the causal relationship between frailty and blood micronutrient levels. Summary-level data for 15 blood micronutrients (copper, selenium, zinc, calcium, iron, magnesium, potassium, folate, carotene, vitamin A, vitamin B6, vitamin B12, vitamin C, vitamin D, and vitamin E) were obtained from people of European ancestry from the Integrative Epidemiology Unit. ⋯ The reverse IVW analysis revealed no significant correlation between micronutrient levels and frailty indices. The study revealed causal links between vitamin D and the risk of frailty. Notably, our findings highlight the necessity of adjuvant vitamin D in frailty management.
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Observational Study
Exploring the mechanism of avenanthramide in the treatment of atherosclerosis based on network pharmacology and molecular docking: An observational study.
Atherosclerosis (AS) is a disease characterized by the buildup of fat and fibrous elements within the walls of arteries and is a primary factor in the occurrence of heart failure and mortality. The potential targets and mechanisms underlying the anti-atherosclerotic effects of avenanthramide (Avn) were investigated using network pharmacology, molecular docking, and molecular dynamics simulations. Target information for Avn A, B, and C was collected from the PubChem and Swiss Target Prediction databases. ⋯ Molecular docking results showed a strong binding affinity between Avn and MMP9 as well as EGFR. Molecular dynamics simulations showed good binding capacity of Avn A, B, and C with EGFR, validating the reliability of the molecular docking results. Avn potentially exerts its effects through multiple targets and displays anti-inflammatory and anti-oxidative stress properties.
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Case Reports
Acupuncture and electroacupuncture for cyclic vomiting syndrome with tachygastria in an adult: A case report.
Cyclic vomiting syndrome (CVS) is characterized by recurrent episodes of acute vomiting lasting <1 week, occurring independently and chronically. Management typically involves lifestyle interventions, supportive care, and preventative medication. In rare cases, CVS persists for decades in adults, requiring a multidisciplinary approach to improve symptoms and quality of life. ⋯ Acupuncture offers a significant and safe approach to relieving symptoms and enhancing the quality of life for patients with nausea and vomiting. Although this is a single case report, the findings suggest that acupuncture can improve treatment compliance and manage symptoms in adults with CVS. Further research, including clinical trials, is required to confirm these findings and understand the underlying mechanisms.
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Observational Study
Analysis of risk factors for poor healing and long-duration pain in conservative treatment of rib fractures.
Rib fractures are a common injury following blunt chest trauma, accounting for approximately 10% of all traumatic injuries and up to 50% of blunt chest trauma cases. These fractures are associated with a high risk of complications, such as pneumothorax, hemothorax, and pulmonary infections, and can significantly impact respiratory function. This study analyzes the risk factors for poor healing and long-duration pain in the conservative treatment of rib fractures, providing a reference for clinicians in choosing conservative treatment and formulating treatment plans. ⋯ Multivariate analysis identified COPD (P = .015), blood calcium (P = .013), and alkaline phosphatase (P = .006) as independent risk factors for poor healing, while diabetes (P = .001), CHD (P = .014), and alkaline phosphatase (P < .001) were independent risk factors for prolonged pain duration. COPD, blood calcium, and alkaline phosphatase are independent risk factors for poor healing in conservative treatment of rib fractures. Diabetes, CHD, and alkaline phosphatase are independent risk factors for long-duration pain in conservative treatment of rib fractures.