Medicine
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Approximately one-fifth ischemic stroke are attributed to cardioembolism. Patients with cardioembolic stroke often develop a more severe disability and a higher risk of stroke recurrence. Cardiac myxoma, although uncommon, can serve as a potentially curable cause of acute embolic strokes. ⋯ Clinicians should be vigilant for skin manifestations of cardiac embolism. In patients with acute ischemic strokes, the presence of cutaneous embolic phenomena could serve as a warning sign of cardioembolism.
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Uveal melanoma (UM) is a common health challenge worldwide as a prevalent intraocular malignancy because of its high mortality rate. However, clinical workers do not have an accurate prognostic tool now. Immune function is closely related to tumor development. ⋯ Our study revealed that immune-related lncRNAs are significant in the clinical diagnosis, treatment and prognosis of UM patients. We successfully constructed a lncRNA-based prognostic risk model which may serve as a future reference for the diagnosis and prognosis of UM. Based on this model we also validated the sensitivity of some cancer drugs, which has implications for the future immunotherapy and drug development.
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The purpose of this study was to assess the prevalence and sociodemographic determinants of depression, anxiety, and stress among vocational college students. 1255 students participated in the cross-sectional study. The Chinese version of the 21-item the Depression Anxiety Stress Scales (DASS-21) was used. Depression was reported in 37.6% of vocational college students, anxiety in 51.6%, and stress in 38.1%. ⋯ Additionally, the likelihood of having depression was higher in non-only-child students (P < .01) and rural family location was a risk factor for stress (P < .001). A higher prevalence of depression, anxiety, and stress was found in vocational college students. Timely and targeted psychological interventions should be taken.
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Pain is a widespread and troubling clinical and social problem with important effects on society and individuals. The purpose is to assess the relationship between pain and eating behavior, macro-micronutrient intake, and dietary inflammation index. The study was carried with a total of 80 patients, consisting of 40 patients diagnosed with pain and 40 patients not diagnosed with pain, who applied to a private hospital in Istanbul as outpatients with a questionnaire face-to-face consisting of questions about sociodemographic characteristics, anthropometric measurements, pain-related information, Eating Attitude Test (EAT-19), and 24-hour food consumption record. ⋯ No difference was detected between the case-control groups with disrupted eating attitudes regarding the median DII score (P > .05). The median DII score was significantly higher in individuals with pain and normal eating attitudes than in those without pain and with disrupted eating attitudes (P < .05). There is a relationship between pain, eating attitudes, and DII, the median DII score of those who had pain and had normal eating attitudes was higher.
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Review Case Reports
A case of paraprotein-negative POEMS syndrome: Case report and literature review.
POEMS syndrome is a rare monoclonal plasma cell disease. The diagnosis of POEMS requires polyradiculoneuropathy and monoclonal plasma proliferating as 2 mandatory criteria, at least 1 of the major criteria (Castleman disease, elevated vascular endothelial growth factor level, and sclerotic bone lesion), and at least 1 of the minor criteria (organomegaly, extravascular volume overload, endocrinopathy, skin changes, papilledema, and thrombocytosis/polycythemia). This multisystem disorder is of high heterogeneity, and few variants of POEMS with no evidence of monoclonal gammopathy have been described, which further complicates the diagnosis in clinical practice. Now, we report a case of paraprotein-negative POEMS syndrome. ⋯ Physicians should pay more attention to the POEMS syndrome, especially the POEMS syndrome variants, which are absence of paraprotein; probably, these variants are just "on the way" to classic POEMS syndrome antiplasma cell therapy, which remains the treatment of choice.