Medicine
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The aim was to explore the application value of dynamic electroencephalography (EEG) combined with brainstem auditory evoked potential (BAEP) in evaluating the degree of vascular stenosis and prognosis in patients with ischemic stroke (IS). This was a retrospective study using clinical data of patients with IS admitted to the First Affiliated Hospital of Chongqing Medical and Pharmaceutical College from March 2020 to March 2022. The degree of vascular stenosis and prognosis of patients were analyzed. ⋯ The DTABR, wave I, wave V, wave III to V, and wave I to V of patients with poor prognosis were higher than those with good prognosis (P < .05). The DTABR, PL of waves I and V, and IPL of waves III to V and I to V in patients with poor prognosis were significantly higher than those in patients with good prognosis (P < .05). EEG combined with BAEP has high value in assessing the degree of vascular stenosis and prognosis in patients with IS, which provides a reference basis for clinical development or adjustment of subsequent intervention plans.
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Observational Study
Retrospective analysis of clinical characteristics and treatment differences between severe and non-severe neonatal types of pneumonia with RSV infection.
Understanding the differences between children with severe and non-severe types of neonatal pneumonia is crucial for clinical treatment and disease management. In this study, we retrospectively analyzed the clinical data of infants with neonatal pneumonia diagnosed as respiratory syncytial virus infection at Wuhan Children's Hospital between December 1, 2022 and November 30, 2023. Further, the recruited subjects were categorized into severe and non-severe groups based on the severity score. ⋯ In terms of life-saving measures, respiratory support and drugs were more frequently required in the critical group than in the noncritical group. The utilization of some specific antibiotics was higher in the critically ill group than in the noncritically ill group. In summary, the study clarified the differences between critically and noncritically ill children with neonatal pneumonia, which could lead to the development of individualized treatment plans and improved quality of life and prognosis of children.
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Observational Study
Analysis of factors affecting early necrosis of the affected finger after surgery in patients with reimplantation of severed fingers.
The study aimed to investigate the factors associated with early necrosis of the finger after reimplantation of broken fingers. Sixty-seven cases of reimplantation of severed fingers in our hospital between January 2023 and December 2023 were retrospectively analyzed. All patients underwent reimplantation of severed fingers and were divided into early necrosis group and non-necrosis group according to the presence or absence of early necrosis of the finger body 7 days after surgery. ⋯ Multifactorial analysis showed that smoking history (OR = 7.255, 95% CI: 1.767-29.782), little finger (OR = 7.040, 95% CI: 1.897-26.130), preoperative ischemia ≥ 8 hours (OR = 15.714, 95% CI: 3.095-79.798), vasospasm (OR = 5.850, 95% CI: 1.563-21.894), crush injury (OR = 5.667, 95% CI: 1.393-23.059), postoperative infection (OR = 5.600, 95% CI: 1.544-20.312), and postoperative hypothermia of the skin (OR = 7.096, 95% CI: 1.872-26.906) were the necrotic post-replantation necrosis after amputation of the finger high-risk factors (OR > 1, P < .05). The risk of early necrosis of the affected finger after reimplantation of an amputated finger is closely related to smoking history, pinky size, preoperative ischemic time of more than 8 hours, vasospasm, crush injuries, postoperative infections, and postoperative hypothermic skin temperature. Preventive measures need to be taken in advance to reduce the risk of necrosis in the affected finger.
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Endosomes play a pivotal role in cellular biology, orchestrating processes such as endocytosis, molecular trafficking, signal transduction, and recycling of cellular materials. This study aims to construct an endosome-related gene (ERG)-derived risk signature for breast cancer prognosis. Transcriptomic and clinical data were retrieved from The Cancer Genome Atlas and the University of California Santa Cruz databases to build and validate the model. ⋯ Ultimately, risk score and age were identified as independent prognostic factors for breast cancer, and these factors were incorporated into a nomogram that demonstrated excellent performance in prognosis assessment. Finally, external cohort validated the dysregulation of the risk score-associated ERGs in breast cancer cells and tissues. This study successfully established an ERG-derived breast cancer risk signature and nomogram, elucidating their potential value in prognosis prediction and evaluation of therapeutic response.
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Bushen-Huoxue-Mingmu-Formula (MMF) has achieved definite clinical efficacy. However, its mechanism is still unclear. ⋯ MMF altered the expression of apoptosis- and autophagy-related proteins and possibly inhibited the Pink1/Parkin signaling pathway, which led to reduced pressurization-induced mitochondrial autophagy in RGCs. This preventive effect of MMF on RGCs can be potentially useful to preserve the viability of RGCs.