JAMA : the journal of the American Medical Association
-
Randomized Controlled Trial Multicenter Study Clinical Trial
Topiramate for migraine prevention: a randomized controlled trial.
Small open-label and controlled trials suggest that the antiepileptic drug topiramate is effective for migraine prevention. ⋯ Topiramate showed significant efficacy in migraine prevention within the first month of treatment, an effect maintained for the duration of the double-blind phase.