JAMA : the journal of the American Medical Association
-
Randomized Controlled Trial Comparative Study
Testing the presumption of consent to emergency treatment for acute ischemic stroke.
-
Editorial Comment
Acetazolamide for pseudotumor cerebri: evidence from the NORDIC trial.
-
Parkinson disease is the second most common neurodegenerative disease worldwide. Although no available therapies alter the underlying neurodegenerative process, symptomatic therapies can improve patient quality of life. ⋯ Strong evidence supports using levodopa and dopamine agonists for motor symptoms at all stages of Parkinson disease. Dopamine agonists and drugs that block dopamine metabolism are effective for motor fluctuations and clozapine is effective for hallucinations. Cholinesterase inhibitors may improve symptoms of dementia and antidepressants and pramipexole may improve depression. Evidence supporting other therapies for motor and nonmotor features is less well established.