JAMA : the journal of the American Medical Association
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Meta Analysis Comparative Study
Pharmacotherapy for Alcohol Use Disorder: A Systematic Review and Meta-Analysis.
Alcohol use disorder affects more than 28.3 million people in the United States and is associated with increased rates of morbidity and mortality. ⋯ In conjunction with psychosocial interventions, these findings support the use of oral naltrexone at 50 mg/d and acamprosate as first-line pharmacotherapies for alcohol use disorder.
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Dental caries is common in children and adolescents aged 5 to 17 years and potentially amenable to primary care screening and prevention. ⋯ Administration of fluoride supplements, fluoride gels, varnish, and sealants in dental or school settings improved caries outcomes. Research is needed on the effectiveness of oral health preventive interventions in primary care settings and to determine the benefits and harms of screening.