The Journal of family practice
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EVIDENCE-BASED ANSWER: Tricyclic antidepressants, gabapentin, and pregabalin effectively reduce pain. Opioids have demonstrated pain relief in 3 RCTs. Capsaicin and the lidocaine 5% patch relieve pain and decrease allodynia.
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Warfarin is certainly a lifesaver--but it can also lead to potentially fatal hypocoagulability. Here we recommend best reversal options based on the type of bleed. ⋯ For major bleeding and elevated INR, hospital admission, vitamin K, fresh frozen plasma, and frequent monitoring are needed. Emergent situations call for hospitalization, clotting factor replacement, and vitamin K administered by slow intravenous infusion.