The Journal of family practice
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These agents are as effective as traditional acute and preventive treatments, cause fewer adverse effects, and can simplify regimens.
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Randomized Controlled Trial
Is low-dose naltrexone effective in chronic pain management?
YES. Low-dose naltrexone is as effective as amitriptyline in the treatment of painful diabetic neuropathy and has a superior safety profile (strength of recommendation [SOR], B; single randomized controlled trial [RCT]). Low-dose naltrexone significantly reduced pain by 32% in inflammatory conditions and 44% in neuropathic conditions (SOR, B; single retrospective cohort study). Doses as low as 5.4 mg were found to reduce pain in 95% of patients with fibromyalgia (SOR, B; single prospective dose-response study).
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Extended treatment for a previous condition provided a key to the diagnosis.
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Case Reports
24-year-old woman • large joint arthralgias • history of type 1 diabetes, seizures, migraines • Dx?
► large joint arthralgias ► history of type 1 diabetes, seizures, migraines.