Memórias do Instituto Oswaldo Cruz
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Mem. Inst. Oswaldo Cruz · Aug 2010
Polymorphisms IL10-819 and TLR-2 are potentially associated with sepsis in Brazilian patients.
Genetic variation in immune response is probably involved in the progression of sepsis and mortality in septic patients. However, findings in the literature are sometimes conflicting or their significance is uncertain. ⋯ Seven of the nine polymorphisms showed similar distributions in allele frequencies between patients and controls. Interestingly, our data suggest that the IL10-819 and TLR-2 polymorphisms may be potential predictors of sepsis.