The Journal of the American Dental Association
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Comparative Study Clinical Trial Controlled Clinical Trial
Efficacy of diphenhydramine hydrochloride for local anesthesia before oral surgery.
The efficacy of diphenhydramine hydrochloride with epinephrine was tested against lidocaine with epinephrine in a double-blind study. Patients with allergic reactions to general local anesthetics were safely and effectively treated with diphenhydramine hydrochloride as an anesthetic alternative.