The Journal of the American Dental Association
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Comparing efficacy and safety of four intravenous sedation regimens in dental outpatients.
Management of patients' fear and anxiety during dental treatment is a primary concern of dental practitioners. Pharmacological strategies used in outpatient dental settings must be both safe and effective. Regimens of intravenously administered sedative drugs were evaluated in a collaborative, multicenter study of outpatients undergoing removal of impacted third molars. ⋯ The results of this large-scale study provide assurance to both the public and the dental profession of the safety of parenteral sedation with these drugs and combinations of these drugs when titrated slowly in the recommended doses by appropriately trained dentists.