The Journal of the American Dental Association
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Randomized Controlled Trial Multicenter Study Comparative Study
Reversal of soft-tissue local anesthesia with phentolamine mesylate in pediatric patients.
The authors evaluated the safety and efficacy of a formulation of phentolamine mesylate (PM) as a local anesthesia reversal agent for pediatric patients. ⋯ PM can help dental clinicians shorten the post-treatment duration of soft-tissue anesthesia and can reduce the number of posttreatment lip and tongue injuries in children.
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Members of the established public health systems and medical community must understand that, in medical surge events, members of the dental profession and other non-traditional disaster health care personnel are an additional source of assistance in response activities. ⋯ Five key national-level programs address the training and organization of health care professionals to support a large-scale disaster program. Because of their training and skills, dental professionals would be valuable additions to these programs and could make significant contributions if natural disasters and/or terrorist events were to occur.
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Randomized Controlled Trial Multicenter Study Comparative Study
Reversal of soft-tissue local anesthesia with phentolamine mesylate in adolescents and adults.
The authors conducted two multicenter, randomized, double-blinded, controlled Phase III clinical trials to study the efficacy and safety of phentolamine mesylate (PM) in shortening the duration and burden of soft-tissue anesthesia. The study involved 484 subjects who received one of four commercially available local anesthetic solutions containing vasoconstrictors for restorative or scaling procedures. ⋯ Clinicians can use PM to accelerate reversal of soft-tissue anesthesia and the associated functional deficits.