Journal of the American Veterinary Medical Association
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J. Am. Vet. Med. Assoc. · Feb 2012
Randomized Controlled TrialClinical efficacy and safety of dexmedetomidine used as a preanesthetic prior to general anesthesia in cats.
To evaluate the clinical efficacy of dexmedetomidine as a preanesthetic medication administered prior to anesthetic induction with ketamine or propofol and with or without isoflurane for maintenance of anesthesia. ⋯ Dexmedetomidine as a preanesthetic was efficacious for clinical use in cats requiring general anesthesia.
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J. Am. Vet. Med. Assoc. · Feb 2012
Case ReportsDexrazoxane treatment of doxorubicin extravasation injury in four dogs.
4 dogs were treated with dexrazoxane for known or suspected doxorubicin extravasation. Records were retrospectively reviewed. Doses and number of doses of dexrazoxane were variable. Dexrazoxane was administered within 2 hours after known extravasation in 3 dogs and 48 hours after suspected extravasation in 1 dog. Additional medical treatments included tissue cooling in all dogs, topically administered dimethyl sulfoxide ointment in 3, and orally administered piroxicam in 1. ⋯ To date, use of dexrazoxane in the management of doxorubicin extravasation has not been reported in dogs. Treatment was successful in 3 of 4 patients. The most effective dosage and timing of administration are unknown; however, there is evidence to suggest that administration within 6 hours after the event is warranted. Further studies are needed to confirm efficacy and to optimize use of this drug in the prevention and treatment of anthracycline extravasation injury in veterinary patients.