Journal of the American Veterinary Medical Association
-
J. Am. Vet. Med. Assoc. · May 2014
Randomized Controlled TrialEfficacy of orally administered maropitant citrate in preventing vomiting associated with hydromorphone administration in dogs.
To evaluate the effectiveness of orally administered maropitant citrate in preventing vomiting after hydromorphone hydrochloride administration in dogs. ⋯ Among the 40 study dogs, the incidence of vomiting associated with hydromorphone administration was 25%. Oral administration of maropitant prevented vomiting but not signs of nausea associated with hydromorphone administration in dogs.
-
J. Am. Vet. Med. Assoc. · May 2014
Randomized Controlled TrialPostoperative comparison of four perioperative analgesia protocols in dogs undergoing stifle joint surgery.
To compare 4 analgesic protocols in dogs undergoing stifle joint surgery. ⋯ Pain scores were similar among groups, and all 4 groups had similar rescue analgesia requirements and similar times to first administration of rescue analgesia. All 4 analgesic protocols provided acceptable analgesia for 24 hours after stifle joint surgery.
-
J. Am. Vet. Med. Assoc. · May 2014
Type II error and statistical power in reports of small animal clinical trials.
To describe reporting of key methodological elements associated with type II error in published reports of small animal randomized controlled trials (RCTs) and to determine the statistical power in a subset of RCTs with negative results. ⋯ The present survey found that small animal RCTs with negative results were often underpowered to detect moderate-to-large effect sizes between study groups. Information needed for critical appraisal was missing from most reports. The potential for clinicians to base treatment decisions on inappropriate interpretations of RCTs was worrisome. Design and reporting of small animal RCTs must be improved.