Journal of the American Veterinary Medical Association
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J. Am. Vet. Med. Assoc. · Jun 2018
Case-control study of plasma mean platelet component concentration and survival analysis for dogs with immune-mediated hemolytic anemia.
OBJECTIVE To determine whether dogs with immune-mediated hemolytic anemia (IMHA) had a low plasma mean platelet component (MPC) concentration and whether MPC was associated with outcome. DESIGN Retrospective case-control study and survival analysis. ANIMALS 95 dogs with IMHA (cases) as well as 95 healthy dogs and 95 sick dogs without IMHA (controls) matched to cases by age, reproductive status, and breed. ⋯ The mean estimated risk of death for dogs with IMHA decreased by 16% for every unit increase in plasma MPC concentration. CONCLUSIONS AND CLINICAL RELEVANCE In dogs with IMHA, platelets appeared to have been activated to a greater degree, as determined by lower plasma MPC concentrations, than in healthy dogs or sick dogs without IMHA. Plasma MPC concentration at initial examination may be useful for predicting prognosis in dogs with IMHA.