Journal of the National Cancer Institute
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J. Natl. Cancer Inst. · May 1995
Multicenter StudyIncidence of second cancers in patients treated for Hodgkin's disease.
Numerous studies of treatment for Hodgkin's disease have demonstrated large increases in the incidence of leukemia in the early years following chemotherapy, although the duration of effect and the specific agents involved are not well understood. Also, some, but not all, studies have indicated that the incidence of certain solid tumors increases following treatment for Hodgkin's disease. ⋯ Without doubt, the benefits of treatment of Hodgkin's disease outweigh the risk of a subsequent malignancy, but data on the carcinogenic effects of radiation and drugs beyond 10 years after treatment continue to be sparse, and future analyses should be directed at long-term survivors.
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J. Natl. Cancer Inst. · May 1995
Vasectomy and prostate cancer: results from a multiethnic case-control study.
Vasectomy, a widely used form of contraception, has been associated in some studies with increased prostate cancer risk. ⋯ The findings of this study do not support previous reports of increased prostate cancer risk associated with vasectomy. However, the altered endocrine profiles of vasectomized control subjects seen in this cross-sectional comparison warrant further evaluation in longitudinal studies.