Journal of the National Cancer Institute
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J. Natl. Cancer Inst. · Jan 1996
Randomized Controlled Trial Clinical TrialRandomized, double-blinded, placebo-controlled study of effect of wheat bran fiber and calcium on fecal bile acids in patients with resected adenomatous colon polyps.
Ongoing epidemiologic and nutritional studies suggest that colorectal carcinogenesis is consistent with complex interactions between genetic susceptibility and environmental and dietary factors. Among the dietary components found to reduce colon cancer risk are high intakes of dietary fiber and calcium. ⋯ Phase III studies of these agents in the prevention of adenoma recurrence are necessary to confirm this hypothesis and have now been initiated at multiple institutions.
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J. Natl. Cancer Inst. · Jan 1996
Multicenter StudyParental alcohol consumption, cigarette smoking, and risk of infant leukemia: a Childrens Cancer Group study.
Whether parental drinking and smoking during pregnancy are associated with an increased risk of cancer in offspring is controversial. There are some indications that maternal alcohol consumption is associated with an elevated risk of acute myeloid leukemia (AML) appearing in very young children. Evidence for an association between maternal smoking during pregnancy and risk of leukemia in offspring has been inconsistent. ⋯ The data suggest that in utero exposure to alcohol may contribute to leukemogenesis involving myeloid cells.