Journal of the National Cancer Institute
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J. Natl. Cancer Inst. · Jan 2001
Meta AnalysisPrognosis and treatment of patients with breast tumors of one centimeter or less and negative axillary lymph nodes.
Uncertainty about prognosis and treatment of axillary lymph node-negative patients with estrogen receptor (ER)-negative or ER-positive invasive breast tumors of 1 cm or less prompted the analysis of data from five National Surgical Adjuvant Breast and Bowel Project randomized clinical trials. ⋯ Chemotherapy and/or tamoxifen should be considered for the treatment of women with ER-negative or ER-positive tumors of 1 cm or less and negative axillary lymph nodes.
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J. Natl. Cancer Inst. · Jan 2001
Randomized Controlled Trial Multicenter Study Clinical TrialGranulocyte colony-stimulating factor in the treatment of high-risk febrile neutropenia: a multicenter randomized trial.
Granulocyte colony-stimulating factors (G-CSFs) have been shown to help prevent febrile neutropenia in certain subgroups of cancer patients undergoing chemotherapy, but their role in treating febrile neutropenia is controversial. The purpose of our study was to evaluate-in a prospective multicenter randomized clinical trial-the efficacy of adding G-CSF to broad-spectrum antibiotic treatment of patients with solid tumors and high-risk febrile neutropenia. ⋯ Adding G-CSF to antibiotic therapy shortens the duration of neutropenia, reduces the duration of antibiotic therapy and hospitalization, and decreases hospital costs in patients with high-risk febrile neutropenia.