Journal of the National Cancer Institute
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J. Natl. Cancer Inst. · May 2001
Progressive resistance to apoptosis in a cell lineage model of human proliferative breast disease.
Proliferative breast disease (PBD) may increase a woman's risk of developing breast cancer, perhaps by decreasing cellular sensitivity to apoptosis. To determine whether resistance to apoptosis develops during PBD, we investigated apoptosis initiated through the Fas pathway in a series of cell lines that recapitulates the morphologic changes of PBD in nude/beige mice. ⋯ Resistance to Fas-mediated apoptosis appears to develop progressively in the MCF-10AT cell series.