Journal of the National Cancer Institute
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J. Natl. Cancer Inst. · Jul 2005
Randomized Controlled Trial Clinical TrialFlexible sigmoidoscopy in the PLCO cancer screening trial: results from the baseline screening examination of a randomized trial.
The Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial is a randomized clinical trial to test the effectiveness of cancer screening, including the effect of flexible sigmoidoscopy screening on colorectal cancer mortality. Here we report findings from the baseline screening flexible sigmoidoscopy examination. ⋯ Acceptance of screening flexible sigmoidoscopy was high. Diagnostic follow-up varied according to polyp size, yet cancer or adenoma detection rates met expectations.
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J. Natl. Cancer Inst. · Jul 2005
A large cohort study of aspirin and other nonsteroidal anti-inflammatory drugs and prostate cancer incidence.
Use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) has consistently been associated with a reduced risk of colon cancer. Recent epidemiologic studies have suggested that the use of NSAIDs, particularly aspirin, may also be associated with a reduced risk of prostate cancer, but the evidence remains limited. ⋯ These results support the hypothesis that long duration regular NSAID use is associated with modestly reduced risk of prostate cancer.