Journal of the National Cancer Institute
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J. Natl. Cancer Inst. · Apr 2007
Multicenter StudyA large cohort study of long-term daily use of adult-strength aspirin and cancer incidence.
Epidemiologic evidence indicates that aspirin use is associated with reduced risks of colon cancer and possibly several other cancers, including prostate and breast cancers. Recent results from the Women's Health Study randomized trial indicate that long-term use of low-dose aspirin (100 mg every other day) does not substantially reduce cancer risk. However, the potential effect of long-term daily use of higher doses of aspirin on cancer incidence remains uncertain. ⋯ Long-term daily use of adult-strength aspirin may be associated with modestly reduced overall cancer incidence in populations among whom colorectal, prostate, and breast cancers are common.
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J. Natl. Cancer Inst. · Apr 2007
Randomized Controlled Trial Multicenter StudyPolychemotherapy for early breast cancer: results from the international adjuvant breast cancer chemotherapy randomized trial.
Survival of patients with early-stage breast cancer is improved following treatment with single-modality tamoxifen, ovarian ablation or suppression, or chemotherapy. The Adjuvant Breast Cancer Trials were designed to ascertain any additional benefits of combined treatment. ⋯ Modest yet sustainable benefits for chemoendocrine therapy occur in women with breast cancer. However, the full impact on overall survival may not emerge for several years.