Journal of the National Cancer Institute
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J. Natl. Cancer Inst. · May 2007
Randomized Controlled Trial Multicenter StudyTamoxifen for the prevention of breast cancer: late results of the Italian Randomized Tamoxifen Prevention Trial among women with hysterectomy.
Initial findings of the Italian Randomized Tamoxifen Prevention Trial found no reduction in risk of breast cancer with tamoxifen use, whereas the National Surgical Adjuvant Breast and Bowel Project Breast Cancer Prevention Trial showed that tamoxifen treatment reduces risk of estrogen receptor-positive breast cancer. Here we present an extended follow-up of the Italian trial. ⋯ Appropriate selection of women at high risk for HR+ disease may improve the risk-benefit ratio of tamoxifen intervention.