Journal of the National Cancer Institute
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J. Natl. Cancer Inst. · Jul 2013
Multicenter StudyProspective observational study of breast cancer treatment outcomes for UK women aged 18-40 years at diagnosis: the POSH study.
Breast cancer at a young age is associated with poor prognosis. The Prospective Study of Outcomes in Sporadic and Hereditary Breast Cancer (POSH) was designed to investigate factors affecting prognosis in this patient group. ⋯ These results confirm the increased frequency of ER-negative tumors and early relapse in young patients and also demonstrate the equally poor longer-term outlook of young patients who have ER-positive tumors with HER2-negative or -positive disease.