Journal of the National Cancer Institute
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J. Natl. Cancer Inst. · Feb 2015
Meta Analysis15q12 variants, sputum gene promoter hypermethylation, and lung cancer risk: a GWAS in smokers.
Lung cancer is the leading cause of cancer-related mortality worldwide. Detection of promoter hypermethylation of tumor suppressor genes in exfoliated cells from the lung provides an assessment of field cancerization that in turn predicts lung cancer. The identification of genetic determinants for this validated cancer biomarker should provide novel insights into mechanisms underlying epigenetic reprogramming during lung carcinogenesis. ⋯ A functional 15q12 variant was identified as a risk factor for gene methylation and lung cancer. The associations could be mediated by GABAergic signaling that drives the smoking-induced mucous cell metaplasia. Our findings also substantiate DSBR-HR as a critical pathway driving epigenetic gene silencing.
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J. Natl. Cancer Inst. · Feb 2015
Review Meta AnalysisAdult weight gain and adiposity-related cancers: a dose-response meta-analysis of prospective observational studies.
Adiposity, measured by body mass index, is implicated in carcinogenesis. While adult weight gain has diverse advantages over body mass index in measuring adiposity, systematic reviews on adult weight gain in relation to adiposity-related cancers are lacking. ⋯ Avoiding adult weight gain itself may confer protection against certain types of cancers, particularly among HRT nonusers.