Journal of the National Cancer Institute
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J. Natl. Cancer Inst. · Jul 2017
Multicenter StudyShared Gene Expression Alterations in Nasal and Bronchial Epithelium for Lung Cancer Detection.
We previously derived and validated a bronchial epithelial gene expression biomarker to detect lung cancer in current and former smokers. Given that bronchial and nasal epithelial gene expression are similarly altered by cigarette smoke exposure, we sought to determine if cancer-associated gene expression might also be detectable in the more readily accessible nasal epithelium. ⋯ These results support that the airway epithelial field of lung cancer-associated injury in ever smokers extends to the nose and demonstrates the potential of using nasal gene expression as a noninvasive biomarker for lung cancer detection.