Journal of the National Cancer Institute
The most recent articles from:
J. Natl. Cancer Inst.
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J. Natl. Cancer Inst. · Dec 2003
Randomized Controlled Trial Clinical TrialVitamin D, calcium supplementation, and colorectal adenomas: results of a randomized trial.
Calcium and vitamin D both appear to have antineoplastic effects in the large bowel. Although these nutrients are inter-related metabolically in bone and in the normal intestine, their potential interactions in large-bowel carcinogenesis are not well understood. ⋯ Calcium supplementation and vitamin D status appear to act largely together, not separately, to reduce the risk of colorectal adenoma recurrence. VDR genotype does not appear to be associated with risk.