Journal of the National Cancer Institute
-
J. Natl. Cancer Inst. · Feb 1975
Lung cancer mortality in World War I veterans with mustard-gas injury: 1919-1965.
A study of the mortality experience of three samples of World War I veterans totaling 7,151 U. S. white males was extended from 1956 through 1965 to learn whether a single exposure to mustard gas with respiratory injury was associated with increased risk of lung cancer in later life. Rosters of men born between 1889 and 1893 [2,718 exposed to mustard gas, 1,855 hospitalized with pneumonia in 1918, and 2,578 with wounds of the extremities (controls)] were traced via the Veterans Administration's death records. ⋯ Observed deaths from lung cancer numbered 69, or 2.5% for the mustard-gas group as compared to 33, or 1.8%, for the pneumonia group and 50, or 1.9%, for the controls. The risk of death from lung cancer among men gassed relative to that for the controls was estimated as 1.3, with 95% confidence limits of 0.9-1.9. These figures failed to make a strong case for a carcinogenic effect, apparently because a suffcient dose of mustard gas was not received,
-
Squamous cell carcinoma was found in association with extensive and progressive oral papillomas in a 1 1/2-year-old male beagle. The neoplasm was in the region of the posterior portion of the right law and evidently originated from the adjacent papillomatous growths. Possible relationship between the duration and extent of papillomatosis and the appearance of malignant change, heretofore not reported, is discussed.