Journal of the National Cancer Institute
-
J. Natl. Cancer Inst. · Mar 2015
Meta AnalysisAdult weight gain and adiposity-related cancers: a dose-response meta-analysis of prospective observational studies.
Adiposity, measured by body mass index, is implicated in carcinogenesis. While adult weight gain has diverse advantages over body mass index in measuring adiposity, systematic reviews on adult weight gain in relation to adiposity-related cancers are lacking. ⋯ Avoiding adult weight gain itself may confer protection against certain types of cancers, particularly among HRT nonusers.
-
J. Natl. Cancer Inst. · Mar 2015
Primary tumor location as a prognostic factor in metastatic colorectal cancer.
We sought to clarify the prognostic impact of primary tumor location in metastatic colorectal cancer (mCRC). ⋯ These data demonstrate that primary tumor location is an important prognostic factor in previously untreated mCRC. Given the consistency across an exploratory set and two confirmatory phase III studies, side of tumor origin should be considered for stratification in randomized trials.
-
J. Natl. Cancer Inst. · Mar 2015
Comparative effectiveness of laparoscopy vs open colectomy among nonmetastatic colon cancer patients: an analysis using the National Cancer Data Base.
Randomized clinical trials showed that laparoscopic colectomy (LC) is superior to open colectomy (OC) in short-term surgical outcomes; however, the generalizability among real-world patients is not clear. ⋯ In routine clinical practice, laparoscopic colectomy is associated with lower 30-day mortality, shorter length of stay, and greater likelihood of adjuvant chemotherapy initiation among stage III colon cancer patients when compared with open colectomy.