Journal of the National Cancer Institute
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J. Natl. Cancer Inst. · Dec 2011
Randomized Controlled Trial Comparative StudyConcurrent chemoradiotherapy vs radiotherapy alone in stage II nasopharyngeal carcinoma: phase III randomized trial.
Concurrent chemoradiotherapy (CCRT) has been shown to improve outcomes for stage III-IV nasopharyngeal carcinoma (NPC) patients compared with radiotherapy (RT) alone, but the effectiveness of the combined therapy for stage II NPC patients is unknown. ⋯ Concurrent chemotherapy and radiotherapy is associated with a considerable survival benefit for patients with stage II NPC.
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J. Natl. Cancer Inst. · Nov 2011
Multicenter Study Comparative StudyPredictors and outcomes of limited resection for early-stage non-small cell lung cancer.
Lobectomy is considered the standard treatment for early-stage non-small cell lung cancer (NSCLC); however, more limited resections are commonly performed. We examined patient and surgeon factors associated with limited resection and compared postoperative and long-term outcomes between sublobar and lobar resections. ⋯ Evidence is statistically inconclusive but suggestive that lobectomy, compared with limited resection, is associated with increased long-term survival for early-stage lung cancer. Clinical, socioeconomic, and surgeon factors appear to be associated with the choice of surgical resection.