Journal of the National Cancer Institute
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J. Natl. Cancer Inst. · Jun 2011
Comparative StudyStatins and prostate cancer diagnosis and grade in a veterans population.
Although prostate cancer is commonly diagnosed, few risk factors for high-grade prostate cancer are known and few prevention strategies exist. Statins have been proposed as a possible treatment to prevent prostate cancer. ⋯ Statin use is associated with statistically significantly reduced risk for total and high-grade prostate cancer, and increased levels of serum cholesterol are associated with higher risk for total and high-grade prostate cancer. These findings indicate that clinical trials of statins for prostate cancer prevention are warranted.
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J. Natl. Cancer Inst. · Jun 2011
Comparative StudyEnd-of-life care for lung cancer patients in the United States and Ontario.
Both the United States and Canada offer government-financed health insurance for the elderly, but few studies have compared care at the end of life for cancer patients between the two systems. ⋯ NSCLC patients in both Ontario and the United States used extensive end-of-life care. Limited availability of hospice care in Ontario and differing attitudes between the United States and Ontario regarding end-of-life care may explain the differences in practice patterns.
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J. Natl. Cancer Inst. · Jun 2011
Activity of the multikinase inhibitor sorafenib in combination with cytarabine in acute myeloid leukemia.
Acute myeloid leukemia (AML) is a genetically heterogeneous cancer that frequently exhibits aberrant kinase signaling. We investigated a treatment strategy combining sorafenib, a multikinase inhibitor with limited single-agent activity in AML, and cytarabine, a key component of AML chemotherapy. ⋯ Sorafenib in combination with cytarabine resulted in strong anti-AML activity in vitro and in vivo. These results warrant clinical evaluation of sorafenib with cytarabine-based regimens in molecularly heterogeneous AML.
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J. Natl. Cancer Inst. · May 2011
Comparative StudyLung cancer risk among smokers of menthol cigarettes.
Menthol cigarettes, preferred by African American smokers, have been conjectured to be harder to quit and to contribute to the excess lung cancer burden among black men in the Unites States. However, data showing an association between smoking menthol cigarettes and increased lung cancer risk compared with smoking nonmenthol cigarettes are limited. The Food and Drug Administration is currently considering whether to ban the sale of menthol cigarettes in the United States. ⋯ The findings suggest that menthol cigarettes are no more, and perhaps less, harmful than nonmenthol cigarettes.